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KMID : 0927720010020040306
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Korean Clinical Diabetes
2001 Volume.2 No. 4 p.306 ~ p.316
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Comparison of Repaglinide and Gliclazide for the Treatment of Type 2 Diabetes
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박철영/Cheol Young Park
김영설/이현철/장학철/Young Seol Kim/Hyun Chul Lee*/Hak Chul Jang?Auth_Info=박철영/경희대학교 의과대학 내과학교실
김영설/연세대학교 의과대학 내과학교실
이현철/성균관대학교 의과대학 삼성제일병원 내과
장학철/
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Abstract
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Background : This study was designed to compare the efficacy and safety of repag linide with gliclazide in a 12-week open-labelled, randomized, parallel group, multi-center study of outpatients with type 2 diabetes.
Methods : A total of 182 patients were screened . 154 patients were randomized in a 1:1 ratio of repaglinide (78 patients) and gliclazide (76 patients). Two randomized patients withdrew from the trial prior to receive any trial medication. At the end of trial, 127 patients completed. The study protocol included a screening visit to assess patient eligibility; a washout period of 2 weeks, a titration period of 4 weeks, and a subsequent 8 week maintenance period. Repaglinide was a dministered preprandially with the three main meals, and gliclazide was taken according to the product labeling .
Results : After 12 weeks treatment, both repaglinide and gliclazide resulted in significant reductions in HbA_(1c) (p<0.001; both treatment groups) and fasting blood glucose (FBG) values (p<0 .001; both treatment groups). Significant reductions in postprandial blood glucose (PPBG) values were found in the repaglinide group at 60 minutes (p<0.05) and at 90 minutes (p<0.05). However, no significant treatment differences in HbA 1c, FBG, or PPBG were observed. Both number of patients and frequency of reported hypoglycemic events appeared to be lower in the repaglinide group than in the gliclazide group (not significant).
Conclusion: Overall, the results showed that repaglinide is well-to lerated and equally effective in controlling HbA_(1c), FBG and PPBG as gliclazide.
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KEYWORD
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Repaglinide (Novo Norm), Gliclazide, Type 2 diabetes
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